Drug safety signals
Proportional reporting ratios and reporting odds ratios for prespecified MedDRA reactions, plus the leading reactions returned by openFDA. Filter by class or by drug. The JAK versus TNF view compares thrombosis and major cardiovascular events with an active comparator.
FAERS data as of 2026-07-30.
Database-wide comparison for JAK inhibitor as a class. The comparator is every other report in the openFDA FAERS extract. Exposure reports in this row set: 265,897. Ingredient mentions, not primary-suspect-only counts. Not incidence.
Proportional reporting ratio
Evans screen: PRR at least 2, chi-square at least 4, and at least 3 reports with the drug and the reaction. A ROR signal means the lower 95% bound is above 1.
| Reaction | Reports | PRR | 95% CI | ROR | 95% CI | Screen |
|---|---|---|---|---|---|---|
| Herpes Zoster | 5,355 | 8.00 | 7.78–8.22 | 8.14 | 7.91–8.37 | EvansROR |
| Tuberculosis | 415 | 2.60 | 2.35–2.86 | 2.60 | 2.36–2.87 | EvansROR |
| Lymphoma | 433 | 2.24 | 2.03–2.46 | 2.24 | 2.04–2.46 | EvansROR |
| Pneumonia | 8,192 | 2.03 | 1.98–2.07 | 2.06 | 2.01–2.10 | EvansROR |
| Thrombosis | 1,941 | 1.92 | 1.84–2.01 | 1.93 | 1.84–2.02 | ROR |
| Pulmonary Embolism | 1,732 | 1.44 | 1.37–1.51 | 1.44 | 1.37–1.51 | ROR |
| Deep Vein Thrombosis | 1,145 | 1.39 | 1.31–1.47 | 1.39 | 1.31–1.47 | ROR |
| Gastric Ulcer | 312 | 1.30 | 1.16–1.45 | 1.30 | 1.16–1.45 | ROR |
| Sepsis | 1,636 | 1.16 | 1.10–1.22 | 1.16 | 1.10–1.22 | ROR |
| Cerebrovascular Accident | 1,948 | 0.90 | 0.86–0.94 | 0.90 | 0.86–0.94 | Below threshold |
| Myocardial Infarction | 1,692 | 0.76 | 0.72–0.79 | 0.75 | 0.72–0.79 | Below threshold |
| Pulmonary Tuberculosis | 37 | 0.68 | 0.49–0.94 | 0.68 | 0.49–0.94 | Below threshold |
| Duodenal Ulcer | 54 | 0.60 | 0.46–0.78 | 0.60 | 0.46–0.78 | Below threshold |
| Gastric Ulcer Haemorrhage | 38 | 0.53 | 0.39–0.73 | 0.53 | 0.39–0.73 | Below threshold |
| Haematemesis | 134 | 0.41 | 0.35–0.49 | 0.41 | 0.35–0.49 | Below threshold |
| Gastrointestinal Haemorrhage | 431 | 0.40 | 0.36–0.44 | 0.40 | 0.36–0.44 | Below threshold |
| Melaena | 101 | 0.36 | 0.29–0.44 | 0.36 | 0.29–0.44 | Below threshold |
| Cerebral Infarction | 111 | 0.35 | 0.29–0.43 | 0.35 | 0.29–0.43 | Below threshold |
| Acute Kidney Injury | 643 | 0.33 | 0.31–0.36 | 0.33 | 0.30–0.35 | Below threshold |
| Hepatic Failure | 103 | 0.27 | 0.22–0.32 | 0.27 | 0.22–0.32 | Below threshold |
Quarterly FAERS mentions
Class-level report counts by receipt quarter. A partial quarter at the end of the openFDA extract is omitted when it is still zero.